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1.
Korean Journal of Hematology ; : 106-111, 1997.
Article in Korean | WPRIM | ID: wpr-720575

ABSTRACT

Dapsone toxicity is evidenced by varying clinical pictures ranging from deep cyanosis in an otherwise alert normal appearing individual to restlessness, dyspnea, extensive hemolytic anemia, methemoglobinemia, sulfhemoglobinemia and serious central nervous system dysfunction. We experienced a case of acute massive dapsone intoxication in 34 years old man due to voluntary ingestion of 25g of this drug as a suicide attempt. A severe methemoglobinemia developed, accompanied by nausea, vomiting, intense cyanosis, headache, and dyspnea. Subsequently moderate hemolytic anemia observed. The patient recovered completely after intensive treatment with methylene blue, activated charcoal hemoperfusion, oral charcoal ingestion, steroid, and conservative treatment. Methylene blue was given by continuous intravenous infusion in order to avoid overdosage. We herein report a case of the acute hemolytic anemia and severe methemoglobinemia induced by massive dapsone intoxication with a review of the literature.


Subject(s)
Adult , Humans , Anemia, Hemolytic , Central Nervous System , Charcoal , Cyanosis , Dapsone , Dyspnea , Eating , Headache , Hemoperfusion , Infusions, Intravenous , Methemoglobinemia , Methylene Blue , Nausea , Psychomotor Agitation , Suicide , Sulfhemoglobinemia , Vomiting
2.
Korean Journal of Hematology ; : 119-122, 1997.
Article in Korean | WPRIM | ID: wpr-720573

ABSTRACT

A 30 year-old women who had had moderately advanced pulmonary tuberculosis and taken antituberculosis regimens including rifampicin was admitted with the symptoms of petechiae on the trunk and extremities and gum bleeding. The thrombocytopenic purpura appeared 20 days after the treatment with rifampicin, and which was rapidly improved with discontinuation of the drug. The diagnosis was confirmed by relapse of thrombocytopenia after retreatment with rifampicin. The paper presents a patient with thrombocytopenia induced by rifampicin and a brief review of pertinent literature.


Subject(s)
Adult , Female , Humans , Diagnosis , Extremities , Gingiva , Hemorrhage , Purpura , Purpura, Thrombocytopenic , Recurrence , Retreatment , Rifampin , Thrombocytopenia , Tuberculosis, Pulmonary
3.
Korean Journal of Gastrointestinal Endoscopy ; : 533-538, 1997.
Article in Korean | WPRIM | ID: wpr-36827

ABSTRACT

The occurrence of double primary cancer of the esopbagus and duodenum is considered very rare. Moreover, it is difficult to manage this type of double cancer because esophageal cancer has a biologic tendency to early metastasis. We report a case of double primary cancer, which we have synchronously confirmed esophageal squamous cell carcinoma and duodenal adenocarcinoma with gastrofiberscopic biopsy, and then treated them by gastrojejunostomy and systemic chemotherapy.


Subject(s)
Adenocarcinoma , Biopsy , Carcinoma, Squamous Cell , Drug Therapy , Duodenum , Esophageal Neoplasms , Gastric Bypass , Neoplasm Metastasis
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